Hledali jste: N-Stearoyl-D-erythro-sphingosine

Katalogové číslo: (BOSSBS-4127R-A680)

Dodavatel: Bioss

Popis: Catalyses the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyses lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11457R-CY5)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-7112R-A488)

Dodavatel: Bioss

Popis: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-7112R-CY5.5)

Dodavatel: Bioss

Popis: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-6276R)

Dodavatel: Bioss

Popis: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Apollo Scientific

Popis: Fumonisin B2 (from Fusarium moniliforme)

Katalogové číslo: (BOSSBS-7541R-A488)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-7541R-A647)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ENZOBMLLP1060050)

Dodavatel: ENZO LIFE SCIENCES

Popis: SEW-2871 is a novel, potent EDG receptor agonist structurally unrelated to sphingosine-1-phosphate and is highly selective for the human S1P1 receptor. It inhibits lymphocyte recirculation in vivo and produces immunosuppression without associated bradycardia which is induced by other less selective S1P agonists. In mice SEW-2871 blocked TNFα induced monocyte adhesion to endothelium.

Měrná jednotka: 1 * 50 mg

New Product Akce

Katalogové číslo: (BOSSBS-7541R-CY7)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Apollo Scientific

Popis: SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

Katalogové číslo: (BOSSBS-11457R-HRP)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2883R-A680)

Dodavatel: Bioss

Popis: This protein belongs to a G protein coupled heptahelical receptor subfamily named Endothelial Cell Differentiation Genes (EDG)that act as receptors for biologically active lysophospholipids. This group consists of two receptor subgroups specific for S1P and LPA respectively. EDG6 is the receptor for lysophospholipid sphingosine 1 phosphate (S1P). S1P elicits diverse physiological effect on most types of cells and tissues. EDG6 may be involved in cell migration processes that are specific for lymphocytes.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-4127R-A750)

Dodavatel: Bioss

Popis: Catalyses the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyses lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11457R-A680)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11457R-A350)

Dodavatel: Bioss

Popis: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Měrná jednotka: 1 * 100 µl

Akce