Hledali jste: N-Carbobenzoxy-D-threonine

Katalogové číslo: (BOSSBS-2739R-CY5)

Dodavatel: Bioss

Popis: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-5537R-CY7)

Dodavatel: Bioss

Popis: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BWRLAP0237)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human Caspase-8 around the phosphorylation site of Threonine 341.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4127)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human Myc around the phosphorylation site of Threonine 358.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4115)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human LIMK1 around the phosphorylation site of Threonine 508.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4122)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human MEK2 around the phosphorylation site of Threonine 394.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4316)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human ETS1 around the phosphorylation site of Threonine 38.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4294)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human Bcl-2 around the phosphorylation site of Threonine 69.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4763)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Threonine 183.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4024)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human Bcl-2 around the phosphorylation site of Threonine 56.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4255)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Threonine 450.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-12373R)

Dodavatel: Bioss

Popis: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. STK33 (serine/threonine kinase 33) is a 514 amino acid protein that belongs to the CaMK (calcium/calmodulin dependent kinase) subfamily of structurally related serine/threonine kinases. Widely expressed at low levels with predominant expression in testis, lung, retina and fetal organs such as brain, heart and spinal cord, STK33 contains one protein kinase domain and functions as a Ser/Thr protein kinase with a possible role in spermatogenesis. The gene encoding STK33 lies within a region on chromosome 11 that has been associated with a variety of defects, including Long QT syndrome, T-cell leukemia, Beckwith-Wiedemann syndrome, Usher syndrome 1C and various other malignancies.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Thermo Fisher Scientific

Popis: Boc-Thr(tBu)-OH 95%

Certifikáty

Katalogové číslo: (BOSSBS-3785R-CY7)

Dodavatel: Bioss

Popis: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BWRLBS4214)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human APP/beta-Amyloid around the phosphorylation site of Threonine 668.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS4441)

Dodavatel: Bioworld Technology

Popis: Synthetic phosphopeptide derived from human PKC alpha around the phosphorylation site of Threonine 505.

Měrná jednotka: 1 * 100 µG

Akce