Hledali jste: Protein+Purification+Dialysis

Popis: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Katalogové číslo: BOSSBS-9356R-A555

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

Katalogové číslo: BOSSBS-4176R-CY7

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

Katalogové číslo: BOSSBS-4176R-A647

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

Katalogové číslo: BOSSBS-4176R-CY3

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Used as an antioxidant & in radiation therapy.

Katalogové číslo: APOSOR9920T-100G

Měrná jednotka: 1 * 100 g

Dodavatel: Apollo Scientific

Akce

Popis: Propafenone hydrochloride

Katalogové číslo: ACRO462390010

Měrná jednotka: 1 * 1 g

Dodavatel: Thermo Fisher Scientific

Akce

Popis: Chlorovodík ∼0.5 M in methanol

Katalogové číslo: H31570.AE

Měrná jednotka: 1 * 100 mL

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Certifikáty Akce

Popis: Sarpogrelate hydrochloride 98%

Katalogové číslo: ACRO461912500

Měrná jednotka: 1 * 250 mg

Dodavatel: Thermo Fisher Scientific

Akce

Popis: Kyselina chlorovodíková 20%, AnalaR NORMAPUR® analytical reagent

Katalogové číslo: 5853.5000

Měrná jednotka: 1 * 5 L

Dodavatel: VWR Chemicals

Bezpečnostní list Certifikáty Akce

Popis: Kyselina chlorovodíková 37,0 - 38,0%, CMOS for microelectronic, J.T.Baker®

Katalogové číslo: 9529-15

Měrná jednotka: 1 * 520 lb

Dodavatel: Avantor

Bezpečnostní list Certifikáty Akce

Popis: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Katalogové číslo: BOSSBS-9356R-A488

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

Katalogové číslo: BOSSBS-4176R-HRP

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Chlorid hydroxylamonný ACS

Katalogové číslo: ACRO412055000

Měrná jednotka: 1 * 500 g

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Certifikáty Akce

Popis: Kyselina chlorovodíková 35 - 38%, AR®, Macron Fine Chemicals™

Katalogové číslo: MACR3128-16

Měrná jednotka: 1 * 2,5 L

Dodavatel: MACRON AVANTOR BRAND

Bezpečnostní list Certifikáty Akce

Popis: 4-(Aminomethyl)pyrimidine hydrochloride 97%

Katalogové číslo: H32582.ME

Měrná jednotka: 1 * 500 mg

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Akce

Popis: Ethanolamine benzoate hydrochloride ≥98%

Katalogové číslo: H25864.14

Měrná jednotka: 1 * 25 g

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Akce