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N-Acetyl-L-glutamic acid ≥99%

Dodavatel: Thermo Scientific

Popis: N-Acetyl-L-glutamic acid ≥99%

Bezpečnostní list

2-Phosphonomethyl pentanedioic acid ≥97% (by HPLC)

Katalogové číslo: (ENZOALX550358M005)

Dodavatel: ENZO LIFE SCIENCES

Popis: Potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase (NAALADase), which is a membrane-bound peptidase that hydrolyses N-acetyl-L-aspartate-L-glutamate (NAAG), a major brain peptide.

Měrná jednotka: 1 * 5 mg

New Product Akce

N/A Each

Ac-Glu(OtBu)-OH 95%

Dodavatel: Thermo Scientific

Popis: Ac-Glu(OtBu)-OH 95%

Certifikáty

Anti-FOLH1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Katalogové číslo: (BOSSBS-2899R-HRP)

Dodavatel: Bioss

Popis: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

N-Acetyl-L-glutamic acid, Sigma-Aldrich®

Dodavatel: Merck

Popis: N-Acetyl-L-glutamic acid, Sigma-Aldrich®

N-Acetyl-Asp-Glu-OH

Dodavatel: ENZO LIFE SCIENCES

Popis: Glutamate receptor ligand

New Product

S. hygroscopicus recombinant PPT N-acetyltransferase (from E. coli)

Katalogové číslo: (PRSI92-657)

Dodavatel: ProSci Inc.

Popis: Phosphinothricin N-acetyltransferase (PAT) is an enzyme that acetylates the free NH2 group of L-phosphinothricin (L-PPT) in the presence of acetyl-CoA as a co-substrate. It is highly specific for L-PPT and does not acetylate other L-amino acids or structurally similar molecules. L-PPT is a glutamate analog that can inhibit glutamine synthetase activity in plants, resulting in the accumulation of ammonia to toxic levels and impairment of photosynthesis. The introduction of a PAT gene into a plant genome can confer resistance to glufosinate herbicide during post-emergent applications.

Měrná jednotka: 1 * 50 µG

Akce

N/A Each

Anti-FOLH1 Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI51-109)

Dodavatel: ProSci Inc.

Popis: PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including poly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate- specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.

Měrná jednotka: 1 * 250 µl

Akce

N/A Each

N-Acetyl-Asp-Glu

Dodavatel: Merck

Popis: Endogenous neurotransmitter localised to neurons with high affinity for metabotropic glutamate receptors, mGluR₃. It is an antagonist at NMDA receptors. Catabolised by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.

Anti-FOLH1 Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI25-996)

Dodavatel: ProSci Inc.

Popis: FOLH1 is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. A mutation in the gene encoding FOLH1 may be associated with impaired intestinal absorption of dietary folates.It is used as an effective diagnostic and prognostic indicator of prostate cancer.This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.

Měrná jednotka: 1 * 50 µG

Akce

N/A Each

Anti-NAGS Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI30-708)

Dodavatel: ProSci Inc.

Popis: NAGS is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.

Měrná jednotka: 1 * 100 µG

Akce