Hledali jste: Boxy+lamin\\u00E1rn\\u00ED

Katalogové číslo: (USBIL1220-12-100)

Dodavatel: US Biological

Popis: Anti-Lamin A,C Mouse Monoclonal Antibody [clone: 2Q1131]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-3254R-HRP)

Dodavatel: Bioss

Popis: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3254R-CY7)

Dodavatel: Bioss

Popis: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Abcam

Popis: Anti-Lamin A + Lamin C Rabbit Monoclonal Antibody [clone: EP4520-16]

Katalogové číslo: (ABCAAB108922-1ML)

Dodavatel: Abcam

Popis: Anti-Lamin A+Lamin B1+Lamin C Rabbit Monoclonal Antibody [clone: EPR4068]

Měrná jednotka: 1 * 1 mL

New Product Akce

Katalogové číslo: (ABCAAB169532-100)

Dodavatel: Abcam

Popis: Anti-Lamin A + Lamin C Rabbit Monoclonal Antibody [clone: EPR4519(2)]

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABCAAB320915-100UL)

Dodavatel: Abcam

Popis: Anti-Lamin A+Lamin B1+Lamin C Rabbit Monoclonal Antibody [clone: EPR4068] (Alexa Fluor® 750)

Měrná jednotka: 1 * 100 µl

New Product Akce

Katalogové číslo: (ABCAAB223943-100)

Dodavatel: Abcam

Popis: Anti-Lamin A+Lamin B1+Lamin C Rabbit Monoclonal Antibody [clone: EPR4068] (Alexa Fluor® 647)

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI031382)

Dodavatel: US Biological

Popis: Anti-Lamin A, C Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Abcam

Popis: Anti-Lamin A + Lamin C (phospho S22) Rabbit Monoclonal Antibody [clone: LaminACS22-CF12]

Katalogové číslo: (BSENR-1697-100)

Dodavatel: Biosensis

Popis: The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm (1). The lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene (2), while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging (3).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI144828)

Dodavatel: US Biological

Popis: Anti-Lamin-B1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (NOVUNBP1-77401IR)

Dodavatel: Novus Biologicals

Popis: Anti-Lamin A + C R453W Mouse Monoclonal Antibody (DyLight® 755) [clone: 12A-2F5]

Měrná jednotka: 1 * 100 Tests

Akce

Katalogové číslo: (NOVUNBP1-77401C)

Dodavatel: Novus Biologicals

Popis: Anti-Lamin A + C R453W Mouse Monoclonal Antibody (DyLight® 650) [clone: 12A-2F5]

Měrná jednotka: 1 * 0,1 mL

Akce

Katalogové číslo: (ABCAAB227176-100)

Dodavatel: Abcam

Popis: Anti-Lamin A + Lamin C Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABCAAB224816-100)

Dodavatel: Abcam

Popis: Anti-Lamin A + Lamin C Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce