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Katalogové číslo: (PRSI33-049)
Dodavatel: ProSci Inc.
Popis: EMAP II (Endothelial monocyte-activating polypeptide 2) is a pro-inflammatory cytokine and participant in apoptotic cell death. It is synthesised as a precursor (pro-EMAP II), lacking a secretion signal peptide. In apoptotic cells, the ~34 kDa pro-form of EMAP II is cleaved by Caspase-7 (and Caspase-3 to a lesser extent) at aspartate 144 to its mature, ~20 kDa form. The mature form of EMAP II has been found to have many different functions. In vivo, it recruits leukocytes to the site of apoptotic cell death. In vitro it has been shown to activate endothelial cells (and the release of von Willebrand factor, E-selectin and P-selectin), neutrophils, and induces macrophage expression of TNFa and TF (tissue factor). EMAP II is also a possible biomarker for brain injury, having been found to be differentially expressed in two types: traumatic injury shows an increase and ischemic injury shows a decrease in EMAP II expression (Dave, et al, 2014).
Měrná jednotka: 1 * 100 µG

New Product


Dodavatel: Cayman Chemical
Popis: ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).1 It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; Item No. 17753), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 breast and CT26 colon cancer mouse xenograft models.

Katalogové číslo: (PRSI91-075)
Dodavatel: ProSci Inc.
Popis: Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in high endothelial venules. It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells. The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling. IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. Human IL-33 is 270 amino acids in length.
Měrná jednotka: 1 * 50 µG


Dodavatel: VWR Collection
Popis: This brightfield, phase contrast microscope is the ideal solution for fast and reliable routine inspections, especially in <i>in vivo</i> cell culture applications.

Dodavatel: Biotium
Popis: Cytotoxic agent that binds and inhibits dihydrofolate reductase. Useful for studying antimetabolite resistance, spontaneous gene amplification, and drug binding. Available conjugated to fluorescein and CF® Dyes.

New Product

Dodavatel: Biotium
Popis: NIR CF® dye free acids are non-reactive molecules and cannot be used for labeling. They can be used as reference standards or controls for corresponding NIR CF® dye-conjugates such as antibodies, proteins, peptides etc. in cell-based and in vivo assays.

Dodavatel: Biotium
Popis: These antibody labelling kits include amine-reactive near-IR CF™ dye as well as all components required for antibody labelling and purification.

Katalogové číslo: (101000122.)
Dodavatel: Polyplus-transfection
Popis: <i>In vivo</i>-jetRNA®+ is a ready-to-use, efficient and stable lipid-based transfection reagent optimised for <i>in vivo</i> mRNA delivery.
Měrná jednotka: 1 * 1 mL

Dodavatel: Biotium
Popis: Near-IR Annexin V fluorescent conjugates can be used to detect apoptotic cells and is suitable for <i>in vivo</i> imaging.

Dodavatel: Polyplus-transfection
Popis: <i>in vivo</i>-jetPEI® reagent provides versatile, reproducible and reliable delivery of all types of nucleic acids (DNA, siRNA, miRNA and more) in animal models, for functional studies and RNA interference experiments using various administration routes.
Katalogové číslo: (BOSSBS-2623R-A647)
Dodavatel: Bioss
Popis: Cytokine that contributes to the inflammatory response in vivo.
Měrná jednotka: 1 * 100 µl


Dodavatel: ENZO LIFE SCIENCES
Popis: Potent irreversible thrombin inhibitor. Inhibits thrombin activation of progelatinase A. Pretreatment with PPACK inhibits thrombin-induced cerebral thromboembolism in vivo.

New Product

Katalogové číslo: (ENZOALX385025M005)
Dodavatel: ENZO LIFE SCIENCES
Popis: Prenyl flavonoid. Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent inhibitor of angiogenesis in vitro and in vivo. Chemopreventive agent against cancer induced by heterocyclic amines.
Měrná jednotka: 1 * 5 mg

New Product


Katalogové číslo: (BOSSBS-2623R-A750)
Dodavatel: Bioss
Popis: Cytokine that contributes to the inflammatory response in vivo.
Měrná jednotka: 1 * 100 µl


Dodavatel: TriLink BioTechnologies
Popis: 2'-Fluoro NTPs are being utilised in an increasing number of applications in research and new drug development. 2'-Fluoro-dUTP is incorporated in both DNA and RNA constructs to improve <em>in vivo</em> stability.

New Product

Dodavatel: Apollo Scientific
Popis: Phleomycin is a glycopeptide antibiotic of the bleomycin family that exhibits in vivo activity against bacteria, eukaryotic microorganisms, plant and animal cells.

Cena na vyžádání
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Daná chemikálie je regulována dle platné legislativy a bude vyžadováno vyplnění formuláře. Jeho včasným vyplněním uspíšíte dodání produktu.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Tento produkt je zablokován vaší organizací. Kontaktujte své nákupní oddělení pro více informací.
Původní produkt již není k dispozici. Zobrazen je náhradní produkt.
Tento produkt již není k dispozici. Podobné produkty můžete vyhledat pomocí VWR katalogových čísel nebo čísel dodavatele uvedených výše. Pokud potřebujete další asistenci, zavolejte na telefonní číslo zákaznického servisu VWR 321 570 321.
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