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Image Unavailable-ENZOADIAGR530D

Anti-AGRN Mouse Monoclonal Antibody

Popis: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development. Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation.
Katalogové číslo: ENZOADIAGR530D
Měrná jednotka: 1 * 50 µG
Dodavatel: ENZO LIFE SCIENCES
Image Unavailable-BOSSBS-3929R-CY7

Anti-ACLY Rabbit Polyclonal Antibody (Cy7®)

Popis: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Katalogové číslo: BOSSBS-3929R-CY7
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-3037R-CY5

Anti-ACLY Rabbit Polyclonal Antibody (Cy5®)

Popis: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Katalogové číslo: BOSSBS-3037R-CY5
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5639R

Anti-STXBP1 Rabbit Polyclonal Antibody

Popis: Munc18 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP binding proteins. It is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Munc18 can interact with syntaxins 1, 2, and 3 but not syntaxin 4. It may play a role in determining the specificity of intracellular fusion reactions. Mutations in Munc18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Two Munc18 isoforms have recently been identified. Munc18-1 has been shown to be primarily expressed in brain, while Munc18-2 is expressed in most tissues.
Katalogové číslo: BOSSBS-5639R
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5916R-A680

Anti-Annexin A9 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Popis: ANXA9 may act as a low affinity receptor for acetylcholine and is expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level). ANXA9 is one of the target molecules recognised by auto in patients with pemphigus vulgaris, a rare, autoimmune skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
Katalogové číslo: BOSSBS-5916R-A680
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0236R-CY7

Anti-CHRM2 Rabbit Polyclonal Antibody (Cy7®)

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0236R-CY7
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0236R-A488

Anti-CHRM2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0236R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0441R-A680

Anti-ChRM2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0441R-A680
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0441R-A555

Anti-CHRM2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0441R-A555
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5916R-A555

Anti-ANXA9 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Popis: ANXA9 may act as a low affinity receptor for acetylcholine and is expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level). ANXA9 is one of the target molecules recognized by auto in patients with pemphigus vulgaris, a rare, autoimmune skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
Katalogové číslo: BOSSBS-5916R-A555
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0236R-CY5.5

Anti-CHRM2 Rabbit Polyclonal Antibody (Cy5.5®)

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0236R-CY5.5
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5916R-A488

Anti-ANXA9 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: ANXA9 may act as a low affinity receptor for acetylcholine and is expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level). ANXA9 is one of the target molecules recognized by auto in patients with pemphigus vulgaris, a rare, autoimmune skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
Katalogové číslo: BOSSBS-5916R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0441R-HRP

Anti-CHRM2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0441R-HRP
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0441R-A647

Anti-CHRM2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Popis: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Katalogové číslo: BOSSBS-0441R-A647
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-1814R-CY5.5

Anti-NRG1 Rabbit Polyclonal Antibody (Cy5.5®)

Popis: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
Katalogové číslo: BOSSBS-1814R-CY5.5
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-13633R-A555

Anti-DOK7 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Popis: The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with muscle-specific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA) — recessively inherited disorders characterized by muscle weakness.
Katalogové číslo: BOSSBS-13633R-A555
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
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