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Anti-LEP Rabbit Polyclonal Antibody

Popis: Anti-LEP Rabbit Polyclonal Antibody
Katalogové číslo: USBIL1670-07K
Měrná jednotka: 1 * 100 µG
Dodavatel: US Biological
Image Unavailable-USBI037738-PE

Anti-LEP Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Popis: Anti-LEP Rabbit Polyclonal Antibody (PE (Phycoerythrin))
Katalogové číslo: USBI037738-PE
Měrná jednotka: 1 * 200 µl
Dodavatel: US Biological
Image Unavailable-USBIL1669-01S

Anti-LEP Rabbit Polyclonal Antibody

Popis: Anti-LEP Rabbit Polyclonal Antibody
Katalogové číslo: USBIL1669-01S
Měrná jednotka: 1 * 250 µG
Dodavatel: US Biological
Image Unavailable-CAYM10005647-50

Cerulenin ≥98%, crystalline solid

Popis: A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.
Katalogové číslo: CAYM10005647-50
Měrná jednotka: 1 * 50 mg
Dodavatel: Cayman Chemical
Image Unavailable-CAYM71740-100

Rosiglitazone ≥98%

Popis: Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions <italic>in vivo</italic>. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC<sub>50</sub> values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active <italic>in vivo</italic> as an antidiabetic agent in the <italic>ob/ob</italic> mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.
Katalogové číslo: CAYM71740-100
Měrná jednotka: 1 * 100 mg
Dodavatel: Cayman Chemical
Image Unavailable-USBIC0107-09A

Anti-CDH11 Goat Polyclonal Antibody

Popis: Anti-CDH11 Goat Polyclonal Antibody
Katalogové číslo: USBIC0107-09A
Měrná jednotka: 1 * 100 µG
Dodavatel: US Biological
Image Unavailable-BOSSBS-11536R-A680

Anti-TUB 1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice, mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population. In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss. The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr and Bardet-Biedl. A candidate for the tub gene has been described. A G - transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron. A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice. It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene.
Katalogové číslo: BOSSBS-11536R-A680
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11536R-CY3

Anti-TUB1 Rabbit Polyclonal Antibody (Cy3®)

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Katalogové číslo: BOSSBS-11536R-CY3
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11536R-A488

Anti-TUB1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Katalogové číslo: BOSSBS-11536R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-USBIL1670-07X

Anti-LEP Rabbit Polyclonal Antibody

Popis: Anti-LEP Rabbit Polyclonal Antibody
Katalogové číslo: USBIL1670-07X
Měrná jednotka: 1 * 50 µl
Dodavatel: US Biological
Image Unavailable-BOSSBS-11536R

Anti-TUB1 Rabbit Polyclonal Antibody

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Katalogové číslo: BOSSBS-11536R
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11536R-A647

Anti-TUB1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Katalogové číslo: BOSSBS-11536R-A647
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11536R-A350

Anti-TUB1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Katalogové číslo: BOSSBS-11536R-A350
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-ROCK110-401-320

Anti-LEP Rabbit Polyclonal Antibody

Popis: This antiserum against Mouse Leptin has been tested for use in ELISA and immunoblotting.  Reactivity in other immunoassays is unknown.  Obesity associated leptin is the product of the OB gene and has been identified with Type II diabetes.
Katalogové číslo: ROCK110-401-320
Měrná jednotka: 1 * 1 mL
Dodavatel: Rockland Immunochemicals
Image Unavailable-USBI045003

Anti-LEP Rabbit Polyclonal Antibody (Biotin)

Popis: Anti-LEP Rabbit Polyclonal Antibody (Biotin)
Katalogové číslo: USBI045003
Měrná jednotka: 1 * 50 µG
Dodavatel: US Biological
Image Unavailable-BOSSBS-4604R-CY5

Anti-LEP Rabbit Polyclonal Antibody (Cy5®)

Popis: Leptin, the product of the ob (obese) gene, is a 16kD protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
Katalogové číslo: BOSSBS-4604R-CY5
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
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