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Procaspase-3-activator (PAC-1) ≥98% (by HPLC), Sigma-Aldrich®

Dodavatel: Merck
Varování


M-Clarity™ quality level = MQ100

P0115-25MG P0115-5MG
SIALP0115-25MGEA 17070 CZK
SIALP0115-25MG SIALP0115-5MG
Procaspase-3-activator (PAC-1) ≥98% (by HPLC), Sigma-Aldrich®
Procaspase-3-activator (PAC1, (4-benzylpiperazino)acetic acid-(3-allyl-2-hydroxybenzylidene)hydrazide)

PAC-1 is a caspase 3 activator.


Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

Vzorec: C₂₃H₂₈N₄O₂
Storage Temperature: Refrigerator
MDL Number: MFCD03302441
CAS číslo: 315183-21-2

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