KrosFlo® hollow fibre membranes for implant technology provide a true-to-life response for drug screening and cancer research. Perfectly suited for implantation, the modified Polyvinylidene Difluoride (mPVDF) hollow fibre membrane is biocompatible, resistant to cell adhesion, hydrophobic and resistant to a wide variety of organic solvents, including most aqueous acids and bases. Furthermore, these hollow fibres can be heat sealed and autoclaved without affecting the molecular weight cut off (500 kDa MWCO) or changing the membrane performance.
- Isolate immune systems cells, viruses and mycoplasma
- Biocompatible inner and outer surface
- Length 34 cm/fiber
The KrosFlo® implant membranes has been shown to be biocompatible in various animal models for periods exceeding 14 days.
Multiple cell lines have been grown both in vitro and in vivo within the KrosFlo® implant membranes. Cell lines grown within KrosFlo® implant membranes, which have been implanted into a host animal, are not subject to immunological attack by the host animal.
KrosFlo® implant membranes containing cancer cell lines have been implanted into mice and used to screen for compounds having anti cancer activity. Similarly, KrosFlo® implant membranes containing HIV infected cell lines have been implanted into mice and used to screen for compounds having anti-HIV activity.
Advantages over xenographic model: 10 day assay versus 60 day assay, smaller assay variability, fewer animals needed, uses lesser amounts of test compounds, multiple cell lines can be tested simultaneously in same animal, compatible with different cell lines.
Inner and outer Ø are 1,0 and 1,2 mm respectively.
