Necrostatin-1 ≥98% (by TLC)
Dodavatel: ENZO LIFE SCIENCES
Synonyms:
5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one, Nec-1
Inhibits necroptosis
Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).
Vzorec:
C₁₃H₁₃N₃OS MW: 259,327 g/mol |
MDL Number:
MFCD00056916 CAS číslo: 4311-88-0 |
Learn more
![](/m-cz.vwr.com/cs_CZ/images/about_vwr_275x315.jpg)
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...