VAS-2870 ≥98% (by HPLC)
Dodavatel: ENZO LIFE SCIENCES
Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM).
- NADPH oxidase inhibitor
White to off-white solid.
Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).
Vzorec:
C₁₈H₁₂N₆OS Storage Temperature: Ambient |
MDL Number:
MFCD03407188 CAS číslo: 722456-31-7 |
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