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Lactacystin ≥99%

Dodavatel: ENZO LIFE SCIENCES

BMLPI1040200 BMLPI1041000
ENZOBMLPI1040200EA 4990 CZK
ENZOBMLPI1040200 ENZOBMLPI1041000
Lactacystin ≥99%
Lactacystin

Key inhibitor for use in proteasome research.


A potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis inhuman monoblast U937 cells. Inhibits NF-kappaB activation by inhibiting IkappaB degradation (IC50=10 µM). Inhibits the ubiquitin proteasome pathway in cell culture. Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells.


Synthetic

Vzorec: C₁₅H₂₄N₂O₇S
CAS číslo: 133343-34-7

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