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K-252a ≥98%

Dodavatel: ENZO LIFE SCIENCES

BMLEI1520100 BMLEI1521000
ENZOBMLEI1520100EA 4590 CZK
ENZOBMLEI1520100 ENZOBMLEI1521000
K-252a ≥98%
K-252a

Protein kinase inhibitor


Alkaloid isolated from soil fungi. General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) (Ki=25nM), trk tyrosine kinase family members (gp140trk; IC50 =3nM) and cGMP-dependent protein kinase (PKG). Binds with high affinity to neuroblastoma membrane (2.7nM), promoting survival of primary neuronal cultures (75nM) and induction of neurite outgrowth in SH-SY5Y neuroblastoma cells along with phosphorylation of pp125 focal adhesion protein tyrosine kinase. Induces apoptosis.

Vzorec: C₂₇H₂₁N₃O₅
MDL Number: MFCD00161522
CAS číslo: 97161-97-2
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=41386f41e0d49c5c7c8abb360a80f364aeb4db16&vid=2b8ae5dc5293603bf81455ba94a6ec799dfc8e34&prid=web&clid=SAPDAM

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