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Lorcainide hydrochloride ≥98% (by TLC)

Dodavatel: ENZO LIFE SCIENCES

BMLNA1430010 BMLNA1430050
ENZOBMLNA1430010EA 3080 CZK
ENZOBMLNA1430010 ENZOBMLNA1430050
Lorcainide hydrochloride ≥98% (by TLC)
Lorcainide hydrochloride

Na+ channel blocker


Possesses both local anesthetic and antiarrhythmic properties (class 1C agent). Elevates the ventricular fibrillation threshold and protects against ouabain-induced arrhythmias in animal models. Its mechamism of action is primarly inhibition of sodium channels in a voltage- and frequency-dependent fashion. Also inhibits the microsomal Na+,K+-ATPase in a concentration-dependent manner (IC50=33.5µM) . Reduces neuronal death in cellular models of hypoxic injury when combined with a glutamate receptor antagonist and blocks aconitine-induced mortality in a rat model (ED50=30mg/kg).

Vzorec: C₂₂H₂₈Cl₂N₂O
MW: 407.379 g/mol
MDL Number: MFCD00055196
CAS číslo: 58934-46-6
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=56293d9ffd727c46d272e5132dcad5dd436b13e3&vid=3d628f9f97572e051c14fca231e6ee3cf5fd18c0&prid=web&clid=SAPDAM

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