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Toluen-α-sulfonylfluorid, white to off white needle crystals

Dodavatel: MP Biomedicals
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Synonyms: PMSF, Phenylmethanesulphonyl fluoride, Phenylmethylsulphonyl fluoride, α-Toluenesulphonyl fluoride

02195381.2 0219538180 0219538101 0219538105 0219538125
ICNA02195381.2EA 766 CZK
ICNA02195381.2 ICNA0219538180 ICNA0219538101 ICNA0219538105 ICNA0219538125
Toluen-α-sulfonylfluorid, white to off white needle crystals
Toluen-α-sulfonylfluorid

Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Inhibits mammalian acetyl cholinesterase, but not those from fish sources.


  • Presentation: White to off white needle crystals
  • Causes sulfonylation of the active-site serine residue
  • A less toxic substitute for the extremely toxic diisopropylfluorophosphate


Phenylmethylsulfonyl fluoride inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase.
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.


Soluble in methanol and ethanol

Vzorec: C₇H₇FO₂S
MW: 174,2 g/mol
Bod varu: 80 - 85 °C (0,3 -rr)
Bod tání: 89…99 °C
Storage Temperature: Refrigerator
MDL Number: MFCD00007424
CAS číslo: 329-98-6
EINECS: 206-350-2
UN: 2928
ADR: 6.1,II

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