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1-(Trimethylsilyl)imidazol silylation reagent, for GC derivatisation

Dodavatel: MACHEREY-NAGEL
Nebezpečí

Synonyms: TSIM, N-(Trimethylsilyl)imidazole, N-(Trimethylsilyl)-1H-imidazole, TMSI, 1-(Trimethylsilyl)-1H-imidazole

701310.110 701310.201 701310.510
MANA701310.110EA 1930 CZK
MANA701310.110 MANA701310.201 MANA701310.510
1-(Trimethylsilyl)imidazol silylation reagent, for GC derivatisation
1-(Trimethylsilyl)imidazole

TSIM is the strongest hydroxyl silylator; reagent of choice for carbohydrates and most steroids (even highly hindered steroids).


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • TSIM selectively derivatizes compounds with different functional groups


The reagent is unique in that it reacts quickly and smooth with hydroxyl (even tert. OH) and carboxyl groups, but not with amines. This characteristic makes TSIM particularly useful in multi-derivatization schemes for compounds with different functional groups, which are to be derivatized differently (e.g., -O-TMS / -N-HFB derivatives of catecholamines). Recommended applications are the derivatizatzion of alcohols, phenols, organic acids, steroids, hormones, glycols, nucleotides and narcotics.

Vzorec: C₆H₁₂N₂Si
MW: 140.26
Bod varu: 94–96 °C (760 mm Hg)
Bod tání: -42
Hustota: 0.961 g/cm³ (d20°/4°)
Bod vzplanutí: 61
MDL Number: MFCD00005280
CAS číslo: 18156-74-6

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