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Ac-DEVD-CHO

Dodavatel: ENZO LIFE SCIENCES

ALX260030M001 ALX260030M005
ENZOALX260030M001EA 2760 CZK
ENZOALX260030M001 ENZOALX260030M005
Ac-DEVD-CHO
Proteiny

Caspase-3 inhibitor


Highly specific, potent and reversible inhibitor of caspase-3. Ki<1 nM for purified caspase-3. IC50=0,2 nM for PARP cleavage in cultured human osteosarcoma cell extracts. In contrast, the caspase-1 (ICE) specific inhibitor YVAD-CHO has a Ki=12 µM for caspase-3 and IC50>10 µM for PARP cleavage in osteosarcoma cell extracts. The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.

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