Human humanin
Dodavatel: ENZO LIFE SCIENCES
Bax inhibitor
Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-beta protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
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