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Anti-FAS Rabbit Polyclonal Antibody

Dodavatel: ENZO LIFE SCIENCES
ADIAAP221D ADIAAP221F
ENZOADIAAP221DEA 8270 CZK
ENZOADIAAP221D ENZOADIAAP221F
Anti-FAS Rabbit Polyclonal Antibody
Protilátky
Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE.  Fas belongs to the tumor necrosis factor receptor (TNFR) family, which includes TNFR1, TNFR2, CD27, CD30 and CD40.  Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells.  Both Fas and TNFR contain a 70 amino acid cytoplasmic “death domain” responsible for transmitting signals for apoptosis.  Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long forms of FLIP. Insertion of an early transposable element in intron 2 of the Fas gene, as in the mouse lpr mutations, causes lymphoproliferation and autoimmunity in mutant mice, suggesting the involvement of Fas in clonal deletion of autoreactive T cells.

  • For Immunohistochemistry, Western Blot

Recognizes human, mouse and rat Fas. Detects a band of ~45kDa by Western blot.

Type: Primary
Antigen: FAS
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
Objednat

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