Tisk…

Anti-CPS1 Mouse Monoclonal Antibody (Purified) [clone: CPS1/1022]

Dodavatel: Biotium
BNUB1022-500 BNUB1022-100
BNUB1022-500EA 14540 CZK
BNUB1022-500 BNUB1022-100
Anti-CPS1 Mouse Monoclonal Antibody (Purified) [clone: CPS1/1022]
Protilátky
This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

Type: Primary
Antigen: CPS1
Clonality: Monoclonal
Clone: CPS1/1022
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Dog, Human
Objednat

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Více About VWR