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Anti-BCL6 Mouse Monoclonal Antibody (CF405S) [clone: BCL6/850]

Dodavatel: Biotium
BNC040850-500 BNC040850-100
BNC040850-500EA 15090 CZK
BNC040850-500 BNC040850-100
Anti-BCL6 Mouse Monoclonal Antibody (CF405S) [clone: BCL6/850]
Protilátky
Recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Type: Primary
Antigen: BCL6
Clonality: Monoclonal
Clone: BCL6/850
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse
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