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Anti-B2M Mouse Monoclonal Antibody (CF647) [clone: C21.48A1]

Dodavatel: Biotium
BNC470433-500 BNC470433-100
BNC470433-500EA 15940 CZK
BNC470433-500 BNC470433-100
Anti-B2M Mouse Monoclonal Antibody (CF647) [clone: C21.48A1]
Protilátky
The antibody recognizes the hidden determinant of β-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. β-2 microglobulin is a 12 kDa protein with a pI of 5.6. Serum β2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. β2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Type: Primary
Antigen: B2M
Clonality: Monoclonal
Clone: C21.48A1
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human, Non-human primates
Objednat

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