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Anti-CTNNB1 Rabbit Polyclonal Antibody (CF488A) [clone: Rabbit PAb]

Dodavatel: Biotium
BNC880376-500 BNC880376-100
BNC880376-500EA 15940 CZK
BNC880376-500 BNC880376-100
Anti-CTNNB1 Rabbit Polyclonal Antibody (CF488A) [clone: Rabbit PAb]
Protilátky
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

Type: Primary
Antigen: CTNNB1
Clonality: Polyclonal
Clone: Rabbit PAb
Conjugation: CF488A
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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