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Anti-PTH Mouse Monoclonal Antibody (CF405S) [clone: 3H9]

Dodavatel: Biotium
BNC040242-500 BNC040242-100
BNC040242-500EA 15940 CZK
BNC040242-500 BNC040242-100
Anti-PTH Mouse Monoclonal Antibody (CF405S) [clone: 3H9]
Protilátky
The epitope of this MAb maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Type: Primary
Antigen: PTH
Clonality: Monoclonal
Clone: 3H9
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
Objednat

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