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Anti-CD36 Mouse Monoclonal Antibody (CF488A) [clone: 185-1G2]

Dodavatel: Biotium
BNC880169-500 BNC880169-100
BNC880169-500EA 15940 CZK
BNC880169-500 BNC880169-100
Anti-CD36 Mouse Monoclonal Antibody (CF488A) [clone: 185-1G2]
Protilátky
Recognizes a protein of 80 kDa-90 kDa, identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This MAb blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.

Type: Primary
Antigen: CD36
Clonality: Monoclonal
Clone: 185-1G2
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human
Objednat

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