Hledali jste: Supelpak\u2122-2SV

Popis: 4-Hydroxybenzylideneacetone ≥97%

Katalogové číslo: A17605.14

Měrná jednotka: 1 * 25 g

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Certifikáty Akce

Popis: trans-2-Methylcyclohexanol, Sigma-Aldrich®

Katalogové číslo: SIAL178829-5G

Měrná jednotka: 1 * 5 g

Dodavatel: Merck

Akce

Popis: trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile ≥99.0% (by HPLC) matrix substance for MALDI-MS, Supelco®

Katalogové číslo: 87884-250MG-F

Měrná jednotka: 1 * 250 mg

Dodavatel: Merck

Akce

Popis: Appearance: Clear light yellow Viscous liquid

Katalogové číslo: ACRO216270010

Měrná jednotka: 1 * 1 kg

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Akce

Popis: β-Ionone (synthetic) 96%

Katalogové číslo: ACRO297135000

Měrná jednotka: 1 * 500 g

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Akce

Popis: PKC inhibitor

Katalogové číslo: ENZOALX550095G001

Měrná jednotka: 1 * 1 g

Dodavatel: ENZO LIFE SCIENCES

Akce

Popis: Ethyl-3-methyl-3-phenylglycidate (mixture of cis and trans isomers), Sigma-Aldrich®

Katalogové číslo: SIALW244406-1KG-K

Měrná jednotka: 1 * 1 kg

Dodavatel: Merck

Akce

Popis: Maleimide 98%

Katalogové číslo: ACRO156711000

Měrná jednotka: 1 * 100 g

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Akce

Popis: Kyselina maleinová ≥99.0%, GPR RECTAPUR®

Katalogové číslo: 85968.180

Měrná jednotka: 1 * 100 g

Dodavatel: VWR Chemicals

Bezpečnostní list Certifikáty Akce

Popis: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).

Katalogové číslo: BOSSBS-4281R-CY7

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).

Katalogové číslo: BOSSBS-4281R-A555

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilises p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilisation and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilising the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).

Katalogové číslo: BOSSBS-4281R-A680

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).

Katalogové číslo: BOSSBS-4281R-FITC

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Organic Standard, Methyl dihydrojasmonate, mixture of cis and trans, ≥96,0% (GC)

Katalogové číslo: 59677-1ML

Měrná jednotka: 1 * 1 mL

Dodavatel: Merck

Akce

Popis: Methyl crotonate, Sigma-Aldrich®

Katalogové číslo: SIAL139459-5ML

Měrná jednotka: 1 * 5 mL

Dodavatel: Merck

Akce

Popis: But-3-en-1-amine, N-BOC protected

Katalogové číslo: APOSOR302285-1G

Měrná jednotka: 1 * 1 g

Dodavatel: Apollo Scientific

Akce